Takayasu arteritis commonly occurs in woman younger than age 50 years; however, it has been reported in patients as young as age 6 months ( Pediatric Takayasu Arteritis). Takayasu arteritis can manifest as isolated, atypical, and/or catastrophic disease. It can involve any or all of the major organ systems. The disease has been reported in all parts of the world, although it appears to be more prevalent in Asians. (See Epidemiology.)
Signs and symptoms
Approximately 10% of patients with Takayasu arteritis are asymptomatic. Clinical manifestations are heterogeneous and include the following:
- Systemic (eg, malaise, arthralgias, fever) – May precede clinical vascular involvement
- Cardiac and vascular (eg, bruit, especially carotid; blood pressure difference of extremities, claudication, hypertension)
- Neurologic (eg, headache, visual disturbance)
- Dermatologic (eg, erythema nodosum)
Diagnosis
The American College of Rheumatology classification for Takayasu arteritis requires the presence of 3 of the following 6 criteria:
- Age of 40 years or younger at disease onset
- Claudication of the extremities
- Decreased pulsation of one or both brachial arteries
- Difference of at least 10 mm Hg in systolic blood pressure between arms
- Bruit over one or both subclavian arteries or the abdominal aorta
- Arteriographic narrowing or occlusion of the entire aorta, its primary branches, or large arteries in the upper or lower extremities that is not due to arteriosclerosis, fibromuscular dysplasia, or other causes
Takayasu arteritis can be divided into the following six types based on angiographic involvement :
- Type I – Branches of the aortic arch
- Type IIa – Ascending aorta, aortic arch, and its branches
- Type IIb – Type IIa region plus thoracic descending aorta
- Type III – Thoracic descending aorta, abdominal aorta, renal arteries, or a combination
- Type IV – Abdominal aorta, renal arteries, or both
- Type V – Entire aorta and its branches
Treatment
Corticosteroids are the mainstay of therapy for active Takayasu arteritis. However, some patients may also require cytotoxic agents, to achieve remission and taper of long-term corticosteroid treatment. Biologic agents (eg, tocilizumab, tumor necrosis factor inhibitors) have shown encouraging results.
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